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KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas.
Cheng Y, Geng H, Cheng SH, Liang P, Bai Y, Li J, Srivastava G, Ng MH, Fukagawa T, Wu X, Chan AT, Tao Q. Cheng Y, et al. Cancer Res. 2010 Aug 15;70(16):6516-26. doi: 10.1158/0008-5472.CAN-09-4566. Epub 2010 Aug 3. Cancer Res. 2010. PMID: 20682794 Free article.
ZNF382 was also frequently methylated in multiple primary tumors (nasopharyngeal, esophageal, colon, gastric, and breast). ...ZNF382 could suppress tumorigenesis through heterochromatin-mediated silencing, as ZNF382 was colocalized and interacted with …
ZNF382 was also frequently methylated in multiple primary tumors (nasopharyngeal, esophageal, colon, gastric, and breast). ... …
Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers.
Li L, Li C, Mao H, Du Z, Chan WY, Murray P, Luo B, Chan AT, Mok TS, Chan FK, Ambinder RF, Tao Q. Li L, et al. Sci Rep. 2016 May 26;6:26591. doi: 10.1038/srep26591. Sci Rep. 2016. PMID: 27225590 Free PMC article.
Through analysis of tumor methylomes, we discovered TET1 as a methylated target, and further confirmed its frequent downregulation/methylation in cell lines and primary tumors of multiple carcinomas and lymphomas, including nasopharyngeal, esophageal, gastric, colorectal, renal, …
Through analysis of tumor methylomes, we discovered TET1 as a methylated target, and further confirmed its frequent downregulation/methylati …